Pentobarbital will decrease the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of osilodrostat by affecting hepatic/intestinal enzyme CYP3... https://socialistener.com/story5808817/i-pentobarbital-icp-diaries