The best way to prevent leg suffering due to peripheral artery disease (PAD) is to have a healthy lifestyle. That means: Individuals with significant limb ischemia/Continual limb-threatening ischemia (CLI/CLTI) at risk for building gangrene will present with limb agony which has progressed from intermittent claudication with exertion to Continual rest soreness. https://sgvasculargrp.com/medical-condition/peripheral-arterial-disease/