The pipecolate area of rapamycin framework seems necessary for rapamycin-binding to FKBP12. This step is required for additional binding of rapamycin on the mTOR kinase, and that is the key enzyme in many biological actions of rapamycin.[forty six] PARP16 is often a tail-anchored endoplasmic reticulum protein needed with the PERK- https://calebv752lqw8.wikicommunication.com/user